Hypotonia is related to ehlers-danlos syndrome, kyphoscoliotic type, 2 and dystonia. An important gene associated with Hypotonia is GNB1 (G Protein Subunit Beta 1), and among its related pathways/superpathways is Vitamin D-sensitive calcium signaling in depression. The drugs Neostigmine and Atropine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain.