Hyperproinsulinemia, also known as hpri, is related to type 1 diabetes mellitus and type 2 diabetes mellitus. An important gene associated with Hyperproinsulinemia is INS (Insulin), and among its related pathways/superpathways is AMP-activated protein kinase signaling. Affiliated tissues include pancreas and kidney, and related phenotypes are hyperinsulinemia and hyperglycemia