Hypereosinophilic Syndrome (HES)

Hypereosinophilic Syndrome, also known as eosinophilia, is related to hypereosinophilic syndrome, idiopathic and primary hypereosinophilic syndrome, and has symptoms including pruritus, myalgia and abdominal pain. An important gene associated with Hypereosinophilic Syndrome is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Azithromycin and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and heart, and related phenotypes are Decreased viability and Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)