Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Thyroid stimulating hormone (TSH) signaling pathway. The drugs Nitric Oxide and Nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include thyroid and heart, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and homeostasis/metabolism