Hypothalamic Disease, also known as hypothalamic dysfunction syndromes, is related to lissencephaly, x-linked, 2 and premature ovarian failure 7. An important gene associated with Hypothalamic Disease is PRL (Prolactin), and among its related pathways/superpathways are GPCR downstream signalling and TGF-Beta Pathway. The drugs Oxytocin and Exenatide have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus and pituitary, and related phenotypes are nervous system and homeostasis/metabolism