Hyperthyroxinemia is related to thyroid hormone resistance, generalized, autosomal dominant and amyloidosis, hereditary, transthyretin-related. An important gene associated with Hyperthyroxinemia is SERPINA7 (Serpin Family A Member 7), and among its related pathways/superpathways are Angiopoietin-like protein 8 regulatory pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include thyroid and pituitary, and related phenotypes are limbs/digits/tail and homeostasis/metabolism