Hypertensive Retinopathy is related to microvascular complications of diabetes 5 and retinal vascular disease. An important gene associated with Hypertensive Retinopathy is VWF (Von Willebrand Factor), and among its related pathways/superpathways are ACE Inhibitor Pathway, Pharmacodynamics and SARS-CoV-2 and ACE2 receptor: molecular mechanisms. Affiliated tissues include retina and eye, and related phenotypes are homeostasis/metabolism and renal/urinary system