Hypertensive Heart Disease is related to cardiovascular system disease and angina pectoris. An important gene associated with Hypertensive Heart Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Metabolism of proteins and p70S6K Signaling. The drugs Angiotensin II and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include heart and cardiac myocytes, and related phenotypes are homeostasis/metabolism and muscle