Hydranencephaly is related to proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome and lissencephaly, x-linked, 2. An important gene associated with Hydranencephaly is NDE1 (NudE Neurodevelopment Protein 1). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain and cortex, and related phenotypes are global developmental delay and blindness