Histoplasmosis, also known as darling disease, is related to african histoplasmosis and american histoplasmosis, and has symptoms including nonproductive cough, headache and loss of appetite. An important gene associated with Histoplasmosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Itraconazole and Ibrexafungerp have been mentioned in the context of this disorder. Affiliated tissues include lung and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and nervous system