Hirata Disease, also known as insulin autoimmune syndrome, is related to graves disease 1 and hypoglycemic coma. An important gene associated with Hirata Disease is INS (Insulin), and among its related pathways/superpathways are IL-9 Signaling Pathways and CD28 co-stimulation. Affiliated tissues include t cells and b cells, and related phenotypes are hyperinsulinemic hypoglycemia and insulin resistance