Heart Block, Congenital, also known as congenital heart block, is related to atrioventricular block and endocardial fibroelastosis. An important gene associated with Heart Block, Congenital is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways are Presenilin-Mediated Signaling and NCAM signaling for neurite out-growth. The drugs Hydroxychloroquine and Autoantibodies have been mentioned in the context of this disorder. Affiliated tissues include Heart and atrioventricular node, and related phenotypes are atrioventricular block and third degree atrioventricular block