Heart Disease, also known as heart failure, is related to heart valve disease and lipoprotein quantitative trait locus, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Heart Disease is NKX2-5 (NK2 Homeobox 5), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Verapamil and Hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include heart and bone marrow.