Heart Valve Disease, also known as valvular heart disease, is related to tricuspid valve disease and aortic valve disease 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Heart Valve Disease is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are ACE Inhibitor Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The drugs Amiodarone and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include Heart and bone.