Heroin Dependence is related to acute stress disorder and premature ejaculation. An important gene associated with Heroin Dependence is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Methadone and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include prefrontal cortex and brain, and related phenotypes are nervous system and homeostasis/metabolism