Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome, also known as hpfh-sickle cell disease syndrome, is related to autosomal dominant beta thalassemia and penile disease. An important gene associated with Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. Related phenotypes are persistence of hemoglobin f and hbs hemoglobin