Hereditary Combined Deficiency of Vitamin K-Dependent Clotting Factors, also known as hereditary combined deficiency of factors ii, vii, ix and x, is related to vitamin k-dependent clotting factors, combined deficiency of, 2 and vitamin k-dependent clotting factors, combined deficiency of, 1. An important gene associated with Hereditary Combined Deficiency of Vitamin K-Dependent Clotting Factors is GGCX (Gamma-Glutamyl Carboxylase), and among its related pathways/superpathways are Diseases of hemostasis and Vitamin K metabolism and activation of dependent proteins.