Hereditary Lymphedema Ic, also known as lymphedema, hereditary, ic, is related to lymphatic malformation 3 and cataract 1, multiple types. An important gene associated with Hereditary Lymphedema Ic is GJC2 (Gap Junction Protein Gamma 2), and among its related pathways/superpathways are Vesicle-mediated transport and G-protein signaling G-Protein alpha-i signaling cascades.