Hereditary Spherocytosis (HS)

Hereditary Spherocytosis, also known as congenital spherocytic hemolytic anemia, is related to spherocytosis, type 1 and bilirubin metabolic disorder, and has symptoms including icterus An important gene associated with Hereditary Spherocytosis is SPTB (Spectrin Beta, Erythrocytic), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Interaction between L1 and Ankyrins. The drugs Papaya and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include spleen and skin, and related phenotypes are increased red cell osmotic fragility and muscle weakness