Hepatic Encephalopathy, also known as portal-systemic encephalopathy, is related to hepatic coma and hepatorenal syndrome. An important gene associated with Hepatic Encephalopathy is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Metabolism and Immune response IL-23 signaling pathway. The drugs Midazolam and Propofol have been mentioned in the context of this disorder. Affiliated tissues include liver and brain, and related phenotypes are homeostasis/metabolism and nervous system