Hemorrhagic Disease, also known as hemorrhagic disorders, is related to vitamin k deficiency bleeding and alpha-2-plasmin inhibitor deficiency, and has symptoms including abnormal bruising, angina pectoris and chest pain. An important gene associated with Hemorrhagic Disease is F11 (Coagulation Factor XI), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Protective Agents and Charcoal have been mentioned in the context of this disorder. Affiliated tissues include prostate and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system