Hemophagocytic Lymphohistiocytosis, Familial, 1 (FHL1)

Hemophagocytic Lymphohistiocytosis, Familial, 1, also known as familial hemophagocytic lymphohistiocytosis, is related to hemophagocytic lymphohistiocytosis, familial, 4 and lymphoproliferative syndrome 1, and has symptoms including ataxia, hemiplegia and icterus. An important gene associated with Hemophagocytic Lymphohistiocytosis, Familial, 1 is UNC13D (Unc-13 Homolog D), and among its related pathways/superpathways are Deregulation of Rab and Rab effector genes in bladder cancer and wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF). The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and t cells, and related phenotypes are fever and anemia