High Molecular Weight Kininogen Deficiency (HMWK DEFICIENCY)

High Molecular Weight Kininogen Deficiency, also known as congenital high-molecular-weight kininogen deficiency, is related to prekallikrein deficiency and angioedema. An important gene associated with High Molecular Weight Kininogen Deficiency is KNG1 (Kininogen 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include endothelial and skeletal muscle, and related phenotypes are prolonged partial thromboplastin time and reduced kininogen activity