Hidradenitis Suppurativa

Hidradenitis Suppurativa, also known as acne inversa, is related to inflammatory bowel disease 1 and dowling-degos disease, and has symptoms including painful nodules, exanthema and pruritus. An important gene associated with Hidradenitis Suppurativa is NCSTN (Nicastrin), and among its related pathways/superpathways are Infectious disease and ERK Signaling. The drugs Triamcinolone and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include skin and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism