Graves Disease 1, also known as thyrotoxicosis, is related to neonatal thyrotoxicosis and thyrotoxic exophthalmos. An important gene associated with Graves Disease 1 is GRD1 (Graves Disease, Susceptiblity To, 1), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Parathyroid hormone and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region