Giant Cell Reparative Granuloma, also known as central giant cell reparative granuloma of jaw, is related to root resorption and hyperparathyroidism, and has symptoms including pain An important gene associated with Giant Cell Reparative Granuloma is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. The drugs Denosumab and Salmon calcitonin have been mentioned in the context of this disorder. Affiliated tissues include bone and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and immune system