Gamma Heavy Chain Disease, also known as franklin disease, is related to heavy chain disease and plasmacytoma, and has symptoms including fever An important gene associated with Gamma Heavy Chain Disease is SUCO (SUN Domain Containing Ossification Factor), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Mesenchymal Stem Cells and Lineage-specific Markers. Affiliated tissues include bone marrow and spleen, and related phenotypes are fatigue and fever