Glycogen Storage Disease Due to Muscle and Heart Glycogen Synthase Deficiency, also known as glycogenosis due to muscle and heart glycogen synthase deficiency, is related to glycogen storage disease 0, muscle. An important gene associated with Glycogen Storage Disease Due to Muscle and Heart Glycogen Synthase Deficiency is GYS1 (Glycogen Synthase 1). Affiliated tissues include heart and skin.