Glucocorticoid Resistance, Generalized, also known as glucocorticoid resistance, is related to leukemia, acute lymphoblastic and leukemia, and has symptoms including fatigue An important gene associated with Glucocorticoid Resistance, Generalized is NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1). The drugs Budesonide and glucocorticoids have been mentioned in the context of this disorder. Affiliated tissues include pituitary and smooth muscle, and related phenotypes are fatigue and hirsutism