Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related (UP-FTD)

Alias:

Primary Progressive Aphasia

Grn-Related Frontotemporal Lobar Degeneration with Tdp43 Inclusions

Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions

Frontotemporal Dementia, Ubiquitin-Positive

Mesulam Syndrome

Ppa

Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions, Susceptibility to

Tau-Negative Frontotemporal Dementia Linked to Chromosome 17

Frontotemporal Dementia with Tdp43 Inclusions, Grn-Related

Degeneration, Frontotemporal Lobar, with Tdp43 Inclusions

Aphasia, Primary Progressive, Susceptibility to

Dementia, Hereditary Dysphasic Disinhibition

Ubiquitin-Positive Frontotemporal Dementia

Aphasia, Primary Progressive

Aphasia Primary Progressive

Frontotemporal Dementia

Ftld-Tdp, Grn-Related

Up-Ftd

Ftldu

Ftdu

Hddd

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Basic Information

Medical Symptom

Gene & Mutation

Related Drugs

Disease Model

References Literature

Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related, also known as primary progressive aphasia, is related to grn-related frontotemporal lobar degeneration and progressive non-fluent aphasia, and has symptoms including personality changes, agitation and memory loss. An important gene associated with Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related is GRN (Granulin Precursor), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Memantine and Escitalopram have been mentioned in the context of this disorder. Affiliated tissues include brain and bone marrow, and related phenotypes are aphasia and hallucinations

Related ID：

MALACARDS：FRN051

OMIM：607485