Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 4, also known as ftdals4, is related to amyotrophic lateral sclerosis 21 and spondylometaphyseal dysplasia, axial. An important gene associated with Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 4 is TBK1 (TANK Binding Kinase 1), and among its related pathways/superpathways are NF-kB (NFkB) Pathway and SARS-CoV-2 innate immunity evasion and cell-specific immune response. Affiliated tissues include temporal lobe and spinal cord, and related phenotypes are hyperreflexia and dysarthria