Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3, also known as ftdals3, is related to inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 and lateral sclerosis. An important gene associated with Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3 is SQSTM1 (Sequestosome 1). Affiliated tissues include temporal lobe and spinal cord, and related phenotypes are hyperreflexia and dysarthria