Frontal Sinus Squamous Cell Carcinoma, also known as epidermoid carcinoma of the frontal sinus, is related to cholesteatoma of middle ear and squamous cell carcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Frontal Sinus Squamous Cell Carcinoma is NKX2-1 (NK2 Homeobox 1). Affiliated tissues include frontal sinus.