Familial Expansile Osteolysis (FEO)

Familial Expansile Osteolysis, also known as mccabe disease, is related to paget's disease of bone 2 and paget disease of bone 2, early-onset. An important gene associated with Familial Expansile Osteolysis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are BAFF in B-Cell Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. Affiliated tissues include bone and cortex, and related phenotypes are conductive hearing impairment and osteolysis