Familial Sick Sinus Syndrome is related to sick sinus syndrome and brugada syndrome. An important gene associated with Familial Sick Sinus Syndrome is GNB2 (G Protein Subunit Beta 2), and among its related pathways/superpathways are Sweet Taste Signaling and Immune response CCR3 signaling in eosinophils. The drugs Angiotensin II and Angiotensinogen have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotype is cardiovascular system.