Familial Cold Autoinflammatory Syndrome

Familial Cold Autoinflammatory Syndrome, also known as familial cold urticaria, is related to familial cold autoinflammatory syndrome 2 and familial cold autoinflammatory syndrome 3. An important gene associated with Familial Cold Autoinflammatory Syndrome is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Infectious disease and Innate Immune System. The drugs Ginseng and Calcium polycarbophil have been mentioned in the context of this disorder. Affiliated tissues include skin and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism