Focal Epithelial Hyperplasia, also known as heck's disease, is related to common wart and acanthoma, and has symptoms including papules and oral manifestations. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include smooth muscle and bone marrow, and related phenotype is hematopoietic system.