Fibrosarcoma of Bone, also known as malignant histiocytosis, is related to histiocytosis and langerhans cell sarcoma, and has symptoms including fever and malaise. An important gene associated with Fibrosarcoma of Bone is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Dactinomycin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow.