Exfoliation Syndrome (XFS)

Exfoliation Syndrome, also known as pseudoexfoliation glaucoma, is related to cataract and morgagni cataract, and has symptoms including progressive decreased vision An important gene associated with Exfoliation Syndrome is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Extracellular matrix organization and TGF-beta receptor signaling activates SMADs. The drugs Bimatoprost and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are cataract and lens subluxation