Excessive Tearing, also known as epiphora, is related to lacrimal apparatus disease and lagophthalmos, and has symptoms including eye manifestations, dacryops and visual disturbance. An important gene associated with Excessive Tearing is CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1), and among its related pathways/superpathways is Thyroxine (thyroid hormone) production. The drugs Prednisolone and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid.