Estrogen Resistance, also known as estrogen insensitivity, is related to ovarian cyst and estrogen-receptor positive breast cancer. An important gene associated with Estrogen Resistance is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Plasma membrane estrogen receptor signaling and Sulfatase and aromatase pathway. Affiliated tissues include breast and uterus, and related phenotypes are osteopenia and increased circulating gonadotropin level