Eosinophilia-Myalgia Syndrome, also known as eosinophilia myalgia syndrome, is related to hypereosinophilic syndrome and alopecia, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Overview of interferons-mediated signaling pathway. The drugs Tryptophan and 5-Hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include skin and spinal cord, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism