Erythema Multiforme Major, also known as erythema exsudativum multiforme majus, is related to erythema multiforme and severe cutaneous adverse reaction. An important gene associated with Erythema Multiforme Major is HLA-B (Major Histocompatibility Complex, Class I, B). The drugs Lenograstim and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and eye.