Erythema Infectiosum, also known as fifth disease, is related to pure red-cell aplasia and aplastic anemia, and has symptoms including exanthema, fever and pruritus. An important gene associated with Erythema Infectiosum is CD40LG (CD40 Ligand), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Vaccines and MF59 oil emulsion have been mentioned in the context of this disorder. Affiliated tissues include skin and bone marrow, and related phenotype is integument.