Epilepsy with Generalized Tonic-Clonic Seizures, also known as tonic-clonic epilepsy, is related to generalized epilepsy with febrile seizures plus, type 2 and febrile seizures, and has symptoms including seizures and non-epileptic convulsion. An important gene associated with Epilepsy with Generalized Tonic-Clonic Seizures is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Transmission across Chemical Synapses and Sweet Taste Signaling. The drugs Lamotrigine and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe and brain, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and nervous system