Enthesopathy, also known as rheumatism, is related to diffuse idiopathic skeletal hyperostosis and arthropathy, and has symptoms including musculoskeletal symptom, myalgia and joint symptom. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase X-Linked), and among its related pathways/superpathways are Endochondral ossification with skeletal dysplasias and Allograft rejection. The drugs Etanercept and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are homeostasis/metabolism and growth/size/body region