End Stage Renal Disease, also known as chronic kidney disease stage 5, is related to microvascular complications of diabetes 5 and familial nephrotic syndrome, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with End Stage Renal Disease is RNLS (Renalase, FAD Dependent Amine Oxidase), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Bardet-Biedl syndrome. The drugs Lactitol and Alprostadil have been mentioned in the context of this disorder. Affiliated tissues include kidney and bone marrow, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism