Dysplastic Nevus Syndrome

Alias:

Familial Atypical Multiple Mole Melanoma Syndrome

Melanoma-Pancreatic Cancer Syndrome

Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma Syndrome

Familial Atypical Multiple Mole-Melanoma

Familial Dysplastic Nevus Syndrome

Familial Atypical Mole Syndrome

B-K Mole Syndrome

Famm-Pc Syndrome

Fammm Syndrome

Familial Atypical Multiple Mole Melanoma

Familial Atypical Mole Melanoma Syndrome

Dysplastic Nevus

Famm Syndrome

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Basic Information

Medical Symptom

Gene & Mutation

Related Drugs

Disease Model

References Literature

Dysplastic Nevus Syndrome, also known as familial atypical multiple mole melanoma syndrome, is related to neuroendocrine tumor of pancreas and skin melanoma. An important gene associated with Dysplastic Nevus Syndrome is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Infectious disease and Homology Directed Repair. The drugs Isotretinoin and Fenretinide have been mentioned in the context of this disorder. Affiliated tissues include skin and pancreas, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation

Related ID：

MALACARDS：DYS002

MESH：D004416