Dry Eye Syndrome, also known as tear film insufficiency, is related to xerophthalmia and keratoconjunctivitis sicca, and has symptoms including dryness of eye and dacryops. An important gene associated with Dry Eye Syndrome is MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Infectious disease and Innate Immune System. The drugs Benzocaine and Dipivefrin have been mentioned in the context of this disorder. Affiliated tissues include eye and salivary gland, and related phenotypes are homeostasis/metabolism and immune system