Drug Dependence

Drug Dependence is related to polysubstance abuse and cannabis dependence. An important gene associated with Drug Dependence is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Ketamine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include prefrontal cortex and brain, and related phenotypes are nervous system and homeostasis/metabolism